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Research in achondroplasia

New research is advancing our knowledge of this disease, and several investigational therapies are being researched to see if they can be used to treat individuals with achondroplasia.

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Scientists are studying 2 main types of therapies:

CNP Analogues

CNP (which stands for C-type natriuretic peptide) is a hormone that plays an important role in bone growth.

CNP activates the NPR-B receptors (natriuretic peptide receptor-B), reducing the effects of the overactive FGFR3 receptors which tell the bones to stop growing.

The Decoy Method

In clinical trials, scientists are studying the “decoy method” for achondroplasia.

Decoys are designed to block the molecules that normally activate the FGFR3 receptors.

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