{"id":2004,"date":"2025-02-20T09:45:29","date_gmt":"2025-02-20T09:45:29","guid":{"rendered":"https:\/\/achondroplasia.biomarin.com\/en-us\/?page_id=2004"},"modified":"2026-05-07T13:47:12","modified_gmt":"2026-05-07T13:47:12","slug":"about-achondroplasia","status":"publish","type":"page","link":"https:\/\/achondroplasia.biomarin.com\/en-us\/about-achondroplasia\/","title":{"rendered":"About Achondroplasia"},"content":{"rendered":"<div id=\"acf-block-69d55668d377d\" class=\"hero hero-small-title hero-large-first-para\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/image-4.png?v=0.97);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-tablet\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/image-4.png?v=0.97);\"><\/div>\n        <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/05\/about-ach.png?v=0.97);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>A Closer Look at Achondroplasia\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Explore how achondroplasia occurs, its impact on bone growth and overall health, along with how you can provide care to help support healthy development.<\/p>\n<p><a class=\"button button-arrow smoothscroll\" href=\"#find-care\" target=\"_self\">FIND CARE NEAR YOU<\/a><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"what-is-achondroplasia\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-67b81bc78f2c4\" class=\"block-wysiwyg\">\n            <h3 style=\"text-align: center\">WHAT IS ACHONDROPLASIA?<\/h3>\n<p style=\"text-align: center\">Achondroplasia is the most common type of skeletal dysplasia, with about 250,000 people diagnosed worldwide.<br \/>\nSkeletal dysplasias are rare genetic conditions that affect bone and cartilage development.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-67d40ccb4f4fe\" class=\"block split-content full-width-content equal-bias bg-band bg-band-secondary bottom-border block-zero-top block-zero-bottom\" >\n\t\t\t<div class=\"background-image background-image-desktop image-right\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/image-5-1024x922.png);\"><\/div>\n\t\t<div class=\"background-image background-image-mobile mobile-image-top\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/image-5-768x692.png);\"><\/div>\n\t\t<div class=\"wrapper wrapper-align-bottom\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                            <div class=\"content-block first-block\">\n                                                                                                <h3><\/h3>\n<h3>A rare genetic condition that inhibits bone growth<\/h3>\n<h5>Bone growth<\/h5>\n<p>Bones play an important role in mobility, daily functioning, and overall health. Most bones begin as cartilage. The process of cartilage developing into bone is known as <strong>endochondral bone growth<\/strong>.<\/p>\n<h5>Growth plates<\/h5>\n<p>Located at the ends of bones, <strong>growth plates<\/strong> are where endochondral bone growth takes place. They remain open from before birth until late adolescence or early adulthood (around ages 15 to 20 years). Once growth plates close, endochondral bone growth stops.<\/p>\n<h5>Inhibited bone growth<\/h5>\n<p>In achondroplasia, endochondral bone growth is <strong>slowed or inhibited and impacts over 90% of bones in the body<\/strong> during developmental years.<\/p>\n<p>&nbsp;<\/p>\n                                                                                    <\/div>\n\n                        <div class=\"content-block second-block\">\n                                                    <\/div>\n                            \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-67c6e2551b5f1\" class=\"block bg-band highlight-text bg-band-primary block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"content-block\">\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<p>The most significant bone growth in the skull, spine, and chest happens during a child\u2019s first 7 years\u2014especially from birth to 2 years old.<\/p>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"find-care\" class=\"block clinic-finder\" data-nonce=\"a65a37b3a7\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"clinic-intro\">\n\t\t\t\t<h3><span>FIND SPECIALIZED CARE NEAR YOU<\/span><\/h3>\n\t\t\t\t\t\t\t\t    <p>Because achondroplasia is rare, it may be difficult to find doctors with the experience you need.\u00a0Feel confident you&#8217;re finding specialized care for your child.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"tabbed-content\">\n\t\t\t\t<div class=\"tabbed-content\">\n\t\t\t\t\t<div class=\"box\">\n\t\t\t\t\t\t<div class=\"tab-content\">\n\t\t\t\t\t\t\t<div class=\"clinic-finder-form\">\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t\t    <p>Locate healthcare providers in your area who have chosen to be part of the Achondroplasia Doctor Finder. <\/p>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"form-item\">\n\t\t\t\t\t\t\t\t\t<div class=\"linear-input\">\n\t\t\t\t\t\t\t\t\t\t<input id=\"clinic-finder-address\" type=\"text\" class=\"text google-places-autocomplete\" placeholder=\"Your address\">\n\t\t\t\t\t\t\t\t\t\t<select id=\"clinic-finder-radius\" class=\"text text-short\">\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"10\">Within 10 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"20\">Within 20 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"30\">Within 30 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"40\">Within 40 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"50\">Within 50 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"100\">Within 100 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"250\">Within 250 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"300\">Within 300 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"500\">Within 500 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t<\/select>\n\t\t\t\t\t\t\t\t\t\t<input type=\"submit\" class=\"button\" value=\"Search\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t                                        <div class=\"footnote\">\n                                            <\/br><em>Search results are not comprehensive and do not reflect any endorsement or certifications from BioMarin. <\/br><br \/>This directory is available for any healthcare provider who chooses to be listed and may not reflect all healthcare professionals in your area.<\/em>                                        <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"no-results\" style=\"display:none;\">\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t        <p>There are no clinics available within the distance you specified. You can expand your search area, or search for a different location instead.<\/p>\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"results\" style=\"display:none;\"><\/div>\n\n\t\t\t\t\t\t\t<div class=\"clinic-load-more\" style=\"display:none;\">\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t\t    <p><a class=\"button button-ghost\" href=\"#\">Load more<\/a><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n                            \t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"clinic-finder-terms-modal\" class=\"clinic-finder-terms white-popup-block mfp-hide\">\n\t<div class=\"box\">\n\t\t<p><a class=\"modal-close\" href=\"#\">Close terms<\/a><\/p>\n\t\t\t\t    <h1>Terms &amp; Conditions<\/h1>\n<ul>\n<li><strong>IMPORTANT:<\/strong> This Achondroplasia Doctor Finder provides information about healthcare professionals not affiliated with BioMarin Pharmaceutical Inc. (&#8220;BioMarin&#8221;).<\/li>\n<li>Healthcare professional enrollment and participation in the Achondroplasia Doctor Finder is voluntary and free of charge and is based solely on information provided by the listed healthcare professionals. The Achondroplasia Doctor Finder is open to all healthcare providers who opt in.<\/li>\n<li>BioMarin makes no express or implied warranties about the accuracy or completeness of information contained in this site\u2019s listings.<\/li>\n<li>Consult with your insurance provider and healthcare team and conduct your own research before selecting a healthcare provider.<\/li>\n<li>You are solely responsible for all communications or other interactions with any healthcare professional listed on the site.<\/li>\n<\/ul>\n<h3>By using this website, you agree that:<\/h3>\n<ul>\n<li>BioMarin makes no endorsement of, recommendations about, nor credentialing of any healthcare professional listed on the site, their insurance network status, or of the skills or services of any such healthcare professional.<\/li>\n<li>BioMarin is neither responsible nor liable for any care furnished by, or failure to provide care by, any healthcare professional identified using the Achondroplasia Doctor Finder.<\/li>\n<li>BioMarin is not responsible for verifying the accuracy of any licenses, skills, education, experience, or ability to practice of any healthcare professional listed on this site. You have the sole responsibility for choosing your healthcare provider and verifying that a particular healthcare professional has the appropriate qualifications and skills to provide medical care.<\/li>\n<li>BioMarin shall not, under any circumstance, be liable to you or any other person for any decision or action taken by you or any person arising from or related to information contained on this site<\/li>\n<\/ul>\n\t\t\n\t\t<div class=\"form-item check-item\">\n\t\t\t<input type=\"checkbox\" id=\"clinic-finder-accept-terms\">\n\t\t\t\t\t\t    <label for=\"clinic-finder-accept-terms\">By checking this box you have acknowledged that you have read and agree with the Terms and Conditions.<\/label>\n\t\t\t\t\t<\/div>\n\n\t\t<div class=\"form-item\">\n\t\t\t<input type=\"submit\" class=\"button button-arrow\" value=\"Get Search Results\">\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"impact\" class=\"block wrapped-content bg-band bg-band-secondary block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-67bf51fb06022\" class=\"block-wysiwyg\">\n            <h3 style=\"text-align: center\">HOW DOES INHIBITED BONE GROWTH AFFECT HEALTH?<\/h3>\n<p class=\"larger-text\" style=\"color: #013a66;text-align: center\">When bone growth is inhibited, there&#8217;s less space inside the body for organs and nerves. For some people with achondroplasia, this can affect physical development and lead to health issues that have a lasting impact.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-67d163fc754dd\" class=\"block split-content full-width-content equal-bias bg-band bg-band-secondary block-zero-top block-zero-bottom\" >\n\t\t\t<div class=\"background-image background-image-desktop image-left\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/skeleton-boy-785x1024.png);\"><\/div>\n\t\t<div class=\"background-image background-image-mobile mobile-image-bottom\" style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/skeleton-boy-768x1002.png);\"><\/div>\n\t\t<div class=\"wrapper wrapper-align-top\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                            <div class=\"content-block first-block\">\n                                                                                                                                                                                    <\/div>\n\n                        <div class=\"content-block second-block\">\n                                                                                                <h4>Inhibited bone growth can affect health in different ways<\/h4>\n                                                                                            \t\t                            \t\t                                                                    <ul class=\"icon-list\">\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Icon-Ear-100x100.png);\">\n                                                    <h5>Smaller inner ear canals (eustachian tubes)<\/h5>\n<p>Can cause frequent ear infections, leading to hearing issues and speech delay<\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Icon-Skull-100x100.png);\">\n                                                    <h5>Smaller opening at the base of the skull<\/h5>\n<p>Can cause compression of the spinal cord, leading to nerve or breathing issues (foramen magnum stenosis)<\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Icon-Airways-100x100.png);\">\n                                                    <h5>Narrow upper airways (nose and mouth)<\/h5>\n<p>Can contribute to sleep apnea<\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Icon-Ribcage-100x100.png);\">\n                                                    <h5>Smaller and more pliable ribcage (in infancy)<\/h5>\n<p>Can affect the lungs and breathing<\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Icon-Backbone-100x100.png);\">\n                                                    <h5>A narrow spinal canal<\/h5>\n<p>Can cause compression of the spinal cord (spinal stenosis)<\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Icon-Limbs-100x100.png);\">\n                                                    <h5>Shorter limbs and disproportionate stature<\/h5>\n<p>Can impact daily function<\/p>\n                                                <\/li>\n                                                                                    <\/ul>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <p><a class=\"button button-download\" href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/03\/AAP_Summary_of_Guidelines_Achondroplasia.pdf?v=0.97\" target=\"_blank\">See care recommendations<\/a><\/p>\n                                                                                                                        <\/div>\n                            \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"support\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom block-remove-bottom-padding\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-67b823ab57ef8\" class=\"block-wysiwyg\">\n            <h3 style=\"text-align: left\">SUPPORT EVERY STEP OF THE WAY<\/h3>\n<p style=\"text-align: left\">Over the course of their life, your child may develop unique needs that require additional consideration from their pediatrician or other specialists. Working closely with your healthcare team and keeping an open dialogue can help you be prepared and provide the right support at the right time.<\/p>\n    <\/div>\n\n<div id=\"acf-block-67c07950ca7a3\" class=\"image-text-block bottom-border block-tight-bottom\">\n            <div class=\"image-block large\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Physical-Development.png?v=0.97\" alt=\"Photo of a child with a healthcare provider\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Tracking physical development\n<\/h3>\n                            <p>During your child\u2019s visits to their pediatrician, their growth and development should be tracked using <strong><a href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/03\/Achondroplasia-Growth-Curves.pdf?v=0.59\" target=\"_blank\" rel=\"noopener\">achondroplasia-specific growth charts<\/a><\/strong>. If certain physical measures like weight or head size are not within the expected range outlined in these charts, your child\u2019s doctor may recommend some additional care and support considerations.<\/p>\n                    <\/div>\n<\/div>\n\n<div id=\"acf-block-67c07950ca83a\" class=\"image-text-block bottom-border block-tight-bottom\">\n            <div class=\"image-block large\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/diego.png?v=0.97\" alt=\"Diego, child with achondroplasia playing\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Monitoring language and motor skills\n<\/h3>\n                            <p>All children grow at their own pace, which means they may <strong><a href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/03\/AAP_Summary_of_Guidelines_Achondroplasia.pdf?v=0.87\" target=\"_blank\" rel=\"noopener\">reach certain milestones at different times<\/a><\/strong>. Most children with achondroplasia will meet expected language milestones; however, frequent ear infections due to inhibited bone growth near the inner ear canals (eustachian tubes) can lead to hearing issues and delay speech development.<\/p>\n<p>Similarly, children with achondroplasia may experience delayed motor skills (such as rolling over, sitting, crawling, and walking) or develop these skills in their own resourceful way (moving with the support of their head or bottom, army crawling, rolling, scooting, and more). Celebrate these moments of creativity while continuing to monitor and support your child&#8217;s unique development.<\/p>\n                    <\/div>\n<\/div>\n\n<div id=\"acf-block-67c07950ca83a\" class=\"image-text-block block-tight-bottom\">\n            <div class=\"image-block large\">\n            <figure>\n                <div class=\"image image-rounded\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2026\/04\/jackson.png?v=0.97\" alt=\"Jackson, child with achondroplasia cooking\" \/>                <\/div>\n            <\/figure>\n        <\/div>\n        <div class=\"content-block\">\n                    <h3>Promoting independence\n<\/h3>\n                            <p>With guidance from your healthcare team, you can help your child become more self-sufficient. Support their independence by creating an environment that&#8217;s accessible, safe, and tailored to their specific needs. Learn more about <a href=\"https:\/\/www.lpaonline.org\/a-guide-to-home-modifications\" target=\"_blank\" rel=\"noopener\"><strong>adaptions<\/strong><\/a> and <strong><a href=\"https:\/\/www.lpaonline.org\/for-parents-and-teachers\" target=\"_blank\" rel=\"noopener\">tips<\/a><\/strong> that can help your child at home, school, and out in the world.<\/p>\n                    <\/div>\n<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"stay-up-to-date\" class=\"block split-content unequal-bias bg-band bg-band-secondary block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/Growth-Charts-e1742234432612.png?v=0.97\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h4>Achondroplasia growth charts<\/h4>\n<p>An important tool to track, predict, and evaluate growth in children with achondroplasia.<\/p>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                        <p><a class=\"button button-download\" href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/03\/Achondroplasia-Growth-Curves.pdf?v=0.97\" target=\"_blank\">Download charts<\/a><\/p>\n                                                                                                                        <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-69d5180c5ed9b\" class=\"block boxed-content top-border\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t                    <h2 class=\"h3\">Explore a treatment option\n<\/h2>\n                \t\t\t\t\n<div id=\"acf-block-69d5180c5ef99\" class=\"block-wysiwyg\">\n            <p>Discover a treatment option for infants and children with achondroplasia.<\/p>\n<p><a class=\"button button-arrow\" href=\"https:\/\/www.voxzogo.com\/en-us\/\" target=\"_blank\" rel=\"noopener\">Learn more<\/a><\/p>\n    <\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-67d29619837c8\" class=\"block call-to-action block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\" style=\"\">\n\t\t\t\t<div class=\"overlay\"><\/div>\n\t\t\t\t<div class=\"cta-content\">\n\t\t\t\t                            <div class=\"cta-image\">\n                            <img decoding=\"async\" class=\"\" src=\"https:\/\/achondroplasia.biomarin.com\/en-us\/wp-content\/uploads\/sites\/14\/2025\/02\/EMAIL_icon@2x-1.png?v=0.97\" alt=\"\" \/>                        <\/div>\n                    \t\t\t\t\t<div class=\"cta-content-main\">\n                        <div class=\"content-block\">\n\t\t\t\t\t        \t\t\t\t\t        \t\t\t\t\t\t        <h2 class=\"h3\">Join the inside story\n<\/h2>\n\t\t\t\t\t\t    \t\t\t\t\t\t    \t\t\t\t\t\t        <p>Gain access to information about achondroplasia, including educational resources and upcoming events in your area. All sent directly to your inbox.<\/p>\n\t\t\t\t\t\t    \t\t\t\t\t    <\/div>\n\t\t\t\t\t                                <div class=\"content-block\">\n                                <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/stay-connected\/\" target=\"_self\">Stay connected<\/a><\/p>\n                            <\/div>\n\t\t\t\t\t                        <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-69d5589660ec2\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-69d5589661275\" class=\"block-wysiwyg\">\n            <p><strong>References:<\/strong><\/p>\n<ul>\n<li><small>Anderson BW, Kortz MW, Black AC, et al. Anatomy, head and neck, skull. In: StatPearls. StatPearls Publishing; 2023. Accessed March 4, 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499834\/<\/small><\/li>\n<li><small>Baron J, S\u00e4vendahl L, De Luca F, et al. Short and tall stature: a new paradigm emerges. <em>Nat Rev Endocrinol<\/em>. 2015;11(12):735-746.<\/small><\/li>\n<li><small>Bartleby. Henry Gray (1825-1861). <em>Anatomy of the Human Body<\/em>. 1918. Fig. 237. Accessed March 4, 2026. https:\/\/www.bartleby.com\/lit-hub\/anatomy-of-the-human-body\/fig-237\/<\/small><\/li>\n<li><small>Berendsen AD, Olsen BR. Bone development. <em>Bone<\/em>. 2015;80:14-18.<\/small><\/li>\n<li><small>Breeland G, Sinkler MA, Menezes RG. Embryology, bone ossification. In: StatPearls. StatPearls Publishing; 2023. Accessed March 4, 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539718\/<\/small><\/li>\n<li><small>Canavese F, Dimeglio A. Normal and abnormal spine and thoracic cage development. <em>World J Orthop<\/em>. 2013;4(4):167-174.<\/small><\/li>\n<li><small>\u00c7ankaya H, Egeli E, Kutluhan A, Kiri\u015f M. Pneumatization of the concha inferior as a cause of nasal obstruction. <em>Rhinology<\/em>. 2001;39(2):109-111.<\/small><\/li>\n<li><small>Clarke B. Normal bone anatomy and physiology. <em>Clin J Am Soc Nephrol<\/em>. 2008;3(suppl 3):S131-S139.<\/small><\/li>\n<li><small>Constantinides C, Landis SH, Jarrett J, et al. Quality of life, physical functioning, and psychosocial function among patients with achondroplasia: a targeted literature review. <em>Disabil Rehabil<\/em>. 2022;44(21):6166-6178.<\/small><\/li>\n<li><small>Cowan PT, Launico MV, Kahai P. Anatomy, bones. In: StatPearls. StatPearls Publishing; 2024. Accessed March 4, 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537199\/<\/small><\/li>\n<li><small>Dimeglio A, Canavese F. The growing spine: how spinal deformities influence normal spine and thoracic cage growth. <em>Eur Spine J<\/em>. 2012;21(1):64-70.<\/small><\/li>\n<li><small>Encyclopaedia Britannica. Science &amp; Tech. Clavicle. Accessed March 4, 2026. https:\/\/www.britannica.com\/science\/clavicle<\/small><\/li>\n<li><small>Encyclopaedia Britannica. Science &amp; Tech. Pelvis. Accessed March 4, 2026. https:\/\/www.britannica.com\/science\/pelvis<\/small><\/li>\n<li><small>Encyclopaedia Britannica. Science &amp; Tech. Skull. Accessed March 4, 2026. https:\/\/www.britannica.com\/science\/skull<\/small><\/li>\n<li><small>Foreman PK, van Kessel F, van Hoorn R, et al. Birth prevalence of achondroplasia: a systematic literature review and meta-analysis. <em>Am J Med Genet A<\/em>. 2020;182(10):2297-2316.<\/small><\/li>\n<li><small>Hall R, Beals K, Neumann H, et al. <em>Introduction to Human Osteology<\/em>. Grand Valley State University; 2008.<\/small><\/li>\n<li><small>Hecht JT, Horton WA, Reid CS, et al. Growth of the foramen magnum in achondroplasia. <em>Am J Med Genet<\/em>. 1989;32(4):528-535.<\/small><\/li>\n<li><small>Hoover-Fong J, Cheung MS, Fano V, et al. Lifetime impact of achondroplasia: current evidence and perspectives on the natural history. <em>Bone<\/em>. 2021;146:115872.<\/small><\/li>\n<li><small>Hoover-Fong J, Scott CI, Jones MC; Committee on Genetics. Health supervision for people with achondroplasia. <em>Pediatrics<\/em>. 2020;145(6):e20201010.<\/small><\/li>\n<li><small>Horton WA, Hall JG, Hecht JT. Achondroplasia.<em> Lancet<\/em>. 2007;370(9582):162-172.<\/small><\/li>\n<li><small>Hsieh YL, Wei X, Wang Y, et al. Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses. <em>Bone<\/em>. 2021;153:116142.<\/small><\/li>\n<li><small>International Center for Limb Lengthening. Growth arrest. Accessed March 4, 2026. https:\/\/www.limblength.org\/conditions\/growth-arrest\/<\/small><\/li>\n<li><small>Jin SW, Sim KB, Kim SD. Development and growth of the normal cranial vault: an embryologic review. <em>J Korean Neurosurg Soc<\/em>. 2016;59(3):192-196.<\/small><\/li>\n<li><small>Johns Hopkins Medicine. Anatomy of the bone. Accessed March 4, 2026. https:\/\/www.hopkinsmedicine.org\/health\/wellness-and-prevention\/anatomy-of-the-bone<\/small><\/li>\n<li><small>Kvist O, Dallora AL, Nilsson O, et al. A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults. <em>Acta Paediatr<\/em>. 2021;110(4):1249-1256.<\/small><\/li>\n<li><small>Legare JM, Modaff P. Achondroplasia. In: GeneReviews. University of Washington, Seattle; 2025. Accessed March 4, 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1152\/<\/small><\/li>\n<li><small>Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. <em>J Endocrinol<\/em>. 2011;211(2):109-121.<\/small><\/li>\n<li><small>Matsushita T, Wilcox WR, Chan YY, et al. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. <em>Hum Mol Genet<\/em>. 2009;18(2):227-240.<\/small><\/li>\n<li><small>Mayo Clinic. Growth plate fracture. Accessed March 4, 2026. https:\/\/www.mayoclinic.org\/diseases-conditions\/growth-plate-fractures\/multimedia\/growth-plate-fracture\/img-20005879<\/small><\/li>\n<li><small>Mitomo K, Matsunaga S, Kitamura K, et al. Sphenoid bone hypoplasia is a skeletal phenotype of cleidocranial dysplasia in a mouse model and patients. <em>Bone<\/em>. 2019;120:176-186.<\/small><\/li>\n<li><small>Musculoskeletal Key. Cranial and pelvic \u201cvertebrae\u201d are they real vertebrae? Accessed March 4, 2026. https:\/\/musculoskeletalkey.com\/cranial-and-pelvic-vertebrae-are-they-real-vertebrae\/<\/small><\/li>\n<li><small>Pauli RM. Achondroplasia: a comprehensive clinical review. <em>Orphanet J Rare Dis<\/em>. 2019;14(1):1.<\/small><\/li>\n<li><small>Savarirayan R, Hoover-Fong J, Ozono K, et al. International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia. <em>Nat Rev Endocrinol<\/em>. 2025;21(5):314-324.<\/small><\/li>\n<li><small>Savarirayan R, Ireland P, Irving M, et al. International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia. <em>Nat Rev Endocrinol<\/em>. 2022;18(3):173-189.<\/small><\/li>\n<li><small>Shahzad F. Pediatric mandible reconstruction: controversies and considerations. <em>Plast Reconstr Surg Glob Open<\/em>. 2020;8(12):e3285.<\/small><\/li>\n<li><small>Witt S, Rohenkohl A, Bullinger M, et al. Understanding, assessing and improving health-related quality of life of young people with achondroplasia &#8211; a collaboration between a patient organization and academic medicine. <em>Pediatr Endocrinol Rev<\/em>. 2017;15(suppl 1):109-118.<\/small><\/li>\n<li><small>Young M, Selleri L, Capellini TD. Genetics of scapula and pelvis development: an evolutionary perspective. <em>Curr Top Dev Biol<\/em>. 2019;132:311-349.<\/small><\/li>\n<li><small>Yu M, Wang SM. Anatomy, head and neck, ethmoid bone. In: StatPearls. StatPearls Publishing; 2025. Accessed March 4, 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544328\/<\/small><\/li>\n<\/ul>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-67b83259ec275\" class=\"block next-previous block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n            <div class=\"link link-prev\">\n                                    <p><a class=\"button button-text button-arrow button-arrow-left\" href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/community-support\/\" target=\"_self\">Community Support<\/a><\/p>\n                            <\/div>\n            <div class=\"link link-next\">\n                                    <p><a class=\"button button-text button-arrow\" href=\"https:\/\/achondroplasia.biomarin.com\/en-us\/diagnosis\/\" target=\"_self\">Diagnosis<\/a><\/p>\n                            <\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-2004","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Achondroplasia Health Impact and Care<\/title>\n<meta name=\"description\" content=\"Understanding achondroplasia, a rare genetic condition, including its health impact and care considerations. 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